MECHANISM OF ACTION:
Omeprazole is a proton pump inhibitor that suppresses gastric acid secretion by specific inhibition of the H+/K+-ATPase in the gastric parietal cell. By acting specifically on the proton pump, Omeprazole blocks the final step in acid production, thus reducing gastric acidity. Domperidone is a peripheral dopamine D2-receptor antagonist, which regulates the motility of gastric and small intestinal smooth muscle. Antiemetic activity is due to the blockade of dopamine receptors in the chemoreceptor trigger zone.
INDICATIONS:
Used for hyperacidity, dyspepsia, gastro-oesophageal reflux disease.
CONTRAINDICATIONS:
Contraindicated in patients with rising prolactin levels and hypersensitivity.
DRUG INTERACTIONS:
Anticholinergics may antagonize the beneficial effects of domperidone in reflux oesophagitis and dyspepsia. Decreased bioavailability of domperidone after prior administration of cimetidine or sodium bicarbonate. Delayed elimination of diazepam, phenytoin and warfarin with omeprazole.
SIDE EFFECTS:
Headache, diarrhoea, skin rash, itching, diarrhoea, abdominal pain, constipation.
DIRECTIONS FOR USE:
It should preferably be taken in the morning before food.
DOSAGE:
As prescribed by the physician.
STORAGE:
Store below 25℃, Protected from moisture and light.
PRESENTATION:
20×15, 10×10 capsules in a cardboard carton
BARCODE:
0108906044105805
0118906044105802
0128906044105809
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