Product Description
DESCRIPTION:
Metronidazole is a nitroimidazole antibiotic medication used particularly for anaerobic bacteria and protozoa. Metronidazole is an antibiotic, amebicide, and antiprotozoal. Clotrimazole is a broad-spectrum antifungal that belongs to the class of imidazole and triazole derivatives.
PACKING:
100x45g
COMPOSITION:
Proplyparaben:
|
Metronidazole
|
B.P.
|
10% w/w
|
|
Clotrimazole
|
B.P.
|
2% w/w
|
|
Methylparaben
|
I.P.
|
0.2% w/w
|
|
I.P.
|
0.1% w/w
|
MECHANISM OF ACTION:
Clotrimazole acts by inhibiting the fungal cytochrome P450 enzyme-Lanosterol 14-demethylase, and thus impairs ergosterol synthesis leading to a cascade of membrane abnormalities in the fungus. Metronidazole is reduced by bacterial nitroreductase to an unstable intermediate, which interacts with DNA effectively, preventing further replication.
INDICATIONS:
Vaginitis due to fungi, mainly candida and/or trichomonas. Superinfection with bacteria sensitive to gram positive-streptococci/staphylococci and gram-negative Bacteroides.
CONTRAINDICATIONS:
Hypersensitivity to any of the ingredients of this medicine.
SIDE EFFECTS:
Burning, stinging, redness, swelling, fever, irritation.
PRECAUTIONS & WARNINGS:
Metronidazole has been shown to be carcinogenic in mice and rats. Unnecessary use of the drug should therefore be avoided.
DOSAGE:
As prescribed by the physician.
PRESENTATION:
45g tube
FOR VAGINAL USE ONLY
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